A depressão é um transtorno mental comum, mas sério, que afeta milhões de pessoas em todo o mundo. Mas afinal, o que causa a depressão? Por que algumas pessoas desenvolvem sintomas depressivos enquanto outras, mesmo em situações parecidas, não são afetadas? A resposta é complexa e envolve uma combinação de fatores genéticos, biológicos, psicológicos, sociais e até comportamentais.
1. Fatores genéticos e químicos do cérebro
Estudos apontam que a predisposição genética tem um papel relevante na depressão. Se você tem familiares com histórico de depressão, ansiedade ou outros transtornos mentais, suas chances de desenvolver esses quadros são maiores.
Além disso, desequilíbrios em neurotransmissores cerebrais, como a serotonina, dopamina e noradrenalina, estão associados à regulação do humor. Quando esses elementos químicos estão em níveis alterados, os sinais da depressão podem surgir com mais facilidade — como tristeza profunda, perda de interesse, irritabilidade e sensação de vazio.
Outro ponto importante é que alterações estruturais no cérebro, especialmente no hipocampo e na amígdala cerebral, também têm sido associadas à depressão clínica.
Lei também: 8 Passos para melhorar sua autoestima
2. Pensamentos negativos são causa ou consequência?

Uma descoberta recente publicada na Psychology Today reforça uma hipótese antiga: os pensamentos negativos são, muitas vezes, a causa das emoções negativas, e não o contrário. Um estudo com mais de 1.600 participantes usando um aplicativo de terapia cognitivo-comportamental (TCC digital) mostrou que, ao reduzir a crença em pensamentos negativos para 0%, os sentimentos negativos diminuíram em até 87%.
Esses resultados confirmam a teoria defendida por filósofos como Epicteto e psicólogos como Aaron Beck: não são os acontecimentos em si que nos afetam, mas a forma como pensamos sobre eles. Portanto, modificar padrões de pensamento negativo pode ser uma das formas mais eficazes de tratar a depressão.
Leia: Pense positivo: 11 Maneiras de Desenvolver o Pensamento Positivo
3. Fatores ambientais e sociais
Eventos de vida estressantes ou traumáticos também estão entre as principais causas da depressão. Isso inclui situações como:
- Perda de um ente querido;
- Divórcio ou término de relacionamento;
- Problemas financeiros;
- Desemprego;
- Abusos físicos ou emocionais;
- Isolamento social.
O impacto desses eventos varia de pessoa para pessoa, mas a repetição ou acúmulo de estresse emocional pode desencadear ou intensificar os sintomas da depressão.
Além disso, discriminação, preconceito, racismo ou bullying aumentam significativamente o risco de depressão, principalmente em grupos vulneráveis.
4. Estilo de vida e comportamentos

A forma como você lida com o dia a dia influencia diretamente sua saúde mental. Entre os fatores comportamentais que aumentam o risco de depressão, destacam-se:
- Falta de sono de qualidade;
- Sedentarismo;
- Má alimentação;
- Isolamento social;
- Baixa autoestima e perfeccionismo.
É importante observar que pensamentos autocríticos excessivos, cobranças internas exageradas e a tendência de se culpar por tudo também são características comuns em pessoas que sofrem de depressão.
5. Fatores hormonais e físicos
Alterações hormonais naturais ou provocadas por condições médicas também podem estar entre as causas da depressão. Entre os exemplos estão:
- Pós-parto (depressão pós-parto);
- Menopausa;
- Problemas na tireoide;
- Doenças crônicas como diabetes, lúpus e fibromialgia.
Além disso, pesquisas mais recentes indicam uma ligação entre processos inflamatórios no corpo e a depressão. Isso sugere que fatores físicos, como inflamações silenciosas e o funcionamento do sistema imunológico, também podem influenciar o surgimento dos sintomas.
6. O papel da tecnologia no tratamento
Os estudos mais recentes sobre TCC digital, como o aplicativo “Feeling Great”, revelam que intervenções digitais bem estruturadas podem aliviar rapidamente sintomas depressivos. Muitos usuários conseguiram reduzir pensamentos negativos de forma eficaz sem precisar de sessões prolongadas de terapia presencial.
Isso não quer dizer que a conexão humana deva ser substituída, mas mostra que tecnologia e terapia podem caminhar juntas. Para muitas pessoas, essas ferramentas são acessíveis, econômicas e eficazes, especialmente para quadros leves a moderados de depressão.
Conclusão: A depressão tem causas múltiplas — e soluções também
A resposta para a pergunta “o que causa a depressão?” não é única. Trata-se de uma combinação de:
- Fatores biológicos (química cerebral, genética);
- Fatores psicológicos (padrões de pensamento, autoestima);
- Fatores sociais (relacionamentos, estresse, perdas);
- Fatores comportamentais (sono, exercícios, hábitos);
- E gatilhos ambientais (traumas, pressões, discriminação).
A boa notícia é que a depressão tem tratamento. Terapias como a TCC, suporte psicológico, medicamentos quando indicados, mudanças de estilo de vida e ferramentas digitais são alternativas que vêm mostrando ótimos resultados.
Se você ou alguém próximo apresenta sinais de depressão, como tristeza constante, perda de interesse, cansaço extremo e pensamentos negativos recorrentes, procure um profissional de saúde mental. Quanto antes o tratamento começar, maiores as chances de recuperação.

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